Microsome biocolloids for rapid drug metabolism and inhibition assessment by LC-MS.
نویسندگان
چکیده
Rat liver microsomes attached to nanoparticles were used for LC-MS studies of CYP3A and 2E1 enzymes in metabolism of N-nitroso compounds. Using these biocolloids, turnover rates were measured within 2 min. Inhibitor IC(50) values for ketoconazole (KET) and 4-methylpyrazole (4-MEP) were estimated.
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ورودعنوان ژورنال:
- Drug metabolism letters
دوره 2 3 شماره
صفحات -
تاریخ انتشار 2008